Sodium methanethiolate → HCID 11774436, compound

HRID 1434959Notes

Reaction equation

HRID 1434959 reaction equation
I[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]3[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]3)[N:12]=2)=[CH:8][CH:7]=1.[CH3:28][S-:29].[Na+]>CO>[CH3:28][S:29][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[S:10][C:9]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][CH:18]3[CH2:23][C:22]([CH3:25])([CH3:24])[NH:21][C:20]([CH3:27])([CH3:26])[CH2:19]3)[N:12]=2)=[CH:8][CH:7]=1

Participants

4

Reactant 2

HCID 4378561Sodium methanethiolateHCID 11191206HCID 11191206, compound

Product 1

HCID 11774436HCID 11774436, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Crude compound of Step B (1.4 g, 2.8 mmol) was dissolved in 10 ml MeOH and 0.4 g (5.6 mmol) sodiumthiomethylate were added. This mixture was refluxed for 7 hours. After evaporation the title compound was purified by chromatography on silicagel (DCM/MeOH/ammonia:9/1/0.1). Yield: 0.82 g (68%).

Workup

  1. temperatureThis mixture was refluxed for 7 hours
  2. customAfter evaporation the title compound
  3. customwas purified by chromatography on silicagel (DCM/MeOH/ammonia:9/1/0.1)

Sources & evidence

ORD record
ord-bf5f711e568b4e64adcb39d4bec98979
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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