HCID 57936256, compound → HCID 57936259, compound

HRID 1434968Notes

Reaction equation

HRID 1434968 reaction equation
[S:1]1[C:5]([C:6]2[CH:11]=[CH:10][N:9]=[C:8]([NH:12][CH:13]3[CH2:18][CH2:17][N:16](CC4C=CC=CC=4)[CH2:15][CH2:14]3)[N:7]=2)=[CH:4][C:3]2[CH:26]=[CH:27][CH:28]=[CH:29][C:2]1=2>CCO.[Pd]>[S:1]1[C:5]([C:6]2[CH:11]=[CH:10][N:9]=[C:8]([NH:12][CH:13]3[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]3)[N:7]=2)=[CH:4][C:3]2[CH:26]=[CH:27][CH:28]=[CH:29][C:2]1=2

Participants

4

Reactant 1

HCID 57936256HCID 57936256, compound

Product 1

HCID 57936259HCID 57936259, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Compound of Example 149 (4.0 g, 10.0 mmol) was dissolved in 100 ml of EtOH and hydrogenated in the presence of 200 mg palladium on charcoal 10% at room temperature and 1 bar for 5 hours. Then the mixture was filtered through Hyflo and evaporated. The crude was purified by chromatography on silicagel (DCM/MeOH/ammonia:8/2/0.2). Yield: 2.76 g (89%).

Workup

  1. filtrationThen the mixture was filtered through Hyflo
  2. customevaporated
  3. customThe crude was purified by chromatography on silicagel (DCM/MeOH/ammonia:8/2/0.2)

Sources & evidence

ORD record
ord-a0d728f6bfd94d5aac0cbcdd71d7bf55
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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