Isopropylamine → HCID 57936238, compound

HRID 1434973Notes

Reaction equation

HRID 1434973 reaction equation
[O:1]1[CH2:3][CH:2]1[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][N:17]=[C:16]([NH:20][CH:21]4[CH2:26][C:25]([CH3:28])([CH3:27])[NH:24][C:23]([CH3:30])([CH3:29])[CH2:22]4)[N:15]=3)[S:11][C:10]=2[CH:31]=1.[CH:32]([NH2:35])([CH3:34])[CH3:33]>C(O)C>[CH:32]([NH:35][CH2:3][CH:2]([OH:1])[CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]2[CH:13]=[C:12]([C:14]3[CH:19]=[CH:18][N:17]=[C:16]([NH:20][CH:21]4[CH2:26][C:25]([CH3:28])([CH3:27])[NH:24][C:23]([CH3:29])([CH3:30])[CH2:22]4)[N:15]=3)[S:11][C:10]=2[CH:31]=1)([CH3:34])[CH3:33]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 57936327HCID 57936327, compound

Product 1

HCID 57936238HCID 57936238, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
70 °C

Procedure

Compound of Example 156 (44 mg, 0.1 mmol) was dissolved in 2 ml ethanol and 100 mg (1.7 mmol) isopropylamine added. This mixture was stirred for 24 hours at 70° C. After evaporation the crude was purified by chromatography on silicagel (DCM/MeOH/ammonia:85/15/1.5). Yield: 38 mg (78%).

Workup

  1. customAfter evaporation the crude
  2. customwas purified by chromatography on silicagel (DCM/MeOH/ammonia:85/15/1.5)

Sources & evidence

ORD record
ord-86b2be7626dd480fa0407c1122b9bfb8
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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