Aluminium lithium hydride → HCID 57936227, compound

HRID 1434975Notes

Reaction equation

HRID 1434975 reaction equation
[S:1]1[C:5]([C:6]2[CH:11]=[CH:10][N:9]=[C:8]([NH:12][CH:13]3[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]#[N:22])[CH2:15][CH2:14]3)[N:7]=2)=[CH:4][C:3]2[CH:23]=[CH:24][CH:25]=[CH:26][C:2]1=2.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[NH2:22][CH2:21][CH2:20][CH2:19][N:16]1[CH2:15][CH2:14][CH:13]([NH:12][C:8]2[N:7]=[C:6]([C:5]3[S:1][C:2]4[CH:26]=[CH:25][CH:24]=[CH:23][C:3]=4[CH:4]=3)[CH:11]=[CH:10][N:9]=2)[CH2:18][CH2:17]1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 57936285HCID 57936285, compound

Product 1

HCID 57936227HCID 57936227, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound of Example 151 was reduced with LAH in THF at 60° C. analogous to Example 53.

Sources & evidence

ORD record
ord-8780fed3a7644745a074058663172a28
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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