HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dibromobenzene → 4-(4-Bromophenyl)-2-(methylthio)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dibromobenzene | HCID 7804 | — |
| Reactant | 2-(Methylthio)-4-(tributylstannyl)pyrimidine | HCID 2763261 | — |
| Catalyst | Palladium Chloride | HCID 24290 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 4-(4-Bromophenyl)-2-(methylthio)pyrimidine | HCID 57936294 | — |
Reaction Steps
2-Methylthio-4-tributylstannylpyrimidine (3.5 g, 7.5 mmol), PdCl2 (525 mg, 0.75 mmol) and 1,4-dibromobenzene (5.3 g, 22.5 mmol) were refluxed in xylene (75 ml) for 30 minutes, filtered and poured directly on a column of silicagel. Chromatography (acetone/hexanes:3/97 to 5/95) gave the title compound as white solid, which was crystallized from hexanes. Yield: 1.1 g (52%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07615562B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-4904a83d9480474791b47579f2f87159 |
| Source note | uspto-grants-2009_11 |