反应详情

2-Methylthio-4-tributylstannylpyrimidine (3.5 g, 7.5 mmol), PdCl2 (525 mg, 0.75 mmol) and 1,4-dibromobenzene (5.3 g, 22.5 mmol) were refluxed in xylene (75 ml) for 30 minutes, filtered and poured directly on a column of silicagel. Chromatography (acetone/hexanes:3/97 to 5/95) gave the title compound as white solid, which was crystallized from hexanes. Yield: 1.1 g (52%).

1. filtrationfiltered
2. additionpoured directly on a column of silicagel