反应详情

A solution of 4-(4-Bromo-phenyl)-2-methylsulfanyl-pyrimidine (1.1 g, 3.91 mmol) in DCM (33 ml) was cooled to 0° C. and treated within 1 hour with several portions of mCPBA (content 70%, 1.1 g, 4.46 mmol) under TLC-control. The reaction mixture was washed with 2N-solution of sodium carbonate, the organic phase dried over sodium sulfate, filtered and evaporated to dryness and purified by chromatography on silicagel (acetone/hexanes:50/50 to 75/25) to give the title compound as white crystals. Yield: 700 mg (60%).

1. washThe reaction mixture was washed with 2N-solution of sodium carbonate
2. dry with materialthe organic phase dried over sodium sulfate
3. filtrationfiltered
4. customevaporated to dryness
5. custompurified by chromatography on silicagel (acetone/hexanes:50/50 to 75/25)