3-(Tributylstannyl)pyridine → [4-(4-Pyridin-3-yl-phenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

HRID 1434987Notes

Reaction equation

HRID 1434987 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]3[CH2:20][C:19]([CH3:22])([CH3:21])[NH:18][C:17]([CH3:24])([CH3:23])[CH2:16]3)[N:9]=2)=[CH:4][CH:3]=1.C([Sn](CCCC)(CCCC)[C:30]1[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=1)CCC>>[N:32]1[CH:33]=[CH:34][CH:35]=[C:30]([C:2]2[CH:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][N:11]=[C:10]([NH:14][CH:15]4[CH2:16][C:17]([CH3:24])([CH3:23])[NH:18][C:19]([CH3:22])([CH3:21])[CH2:20]4)[N:9]=3)=[CH:4][CH:3]=2)[CH:31]=1

Participants

3

Reactant 2

HCID 34838483-(Tributylstannyl)pyridineHCID 57936126[4-(4-Bromophenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Product 1

HCID 57936150[4-(4-Pyridin-3-yl-phenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Procedure

The title compound was prepared analogous to Step D of Example 172, starting from [4-(4-bromophenyl)-pyrimidin-2-yl]-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 3-tributylstannanyl-pyridine. Yield: 45 mg (24%).

Sources & evidence

ORD record
ord-3bc1673fe6c449139fdc72c182e8a604
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

Loading…