4-Amino-2,2,6,6-tetramethylpiperidine → HCID 57936130, compound

HRID 1434991Notes

Reaction equation

HRID 1434991 reaction equation
CS([C:4]1[N:9]=[C:8]([C:10]2[CH:11]=[CH:12][C:13]([C:16]#[C:17][C:18]([NH2:21])([CH3:20])[CH3:19])=[N:14][CH:15]=2)[CH:7]=[CH:6][N:5]=1)=O.[NH2:22][CH:23]1[CH2:28][C:27]([CH3:30])([CH3:29])[NH:26][C:25]([CH3:32])([CH3:31])[CH2:24]1>>[NH2:21][C:18]([CH3:20])([CH3:19])[C:17]#[C:16][C:13]1[N:14]=[CH:15][C:10]([C:8]2[CH:7]=[CH:6][N:5]=[C:4]([NH:22][CH:23]3[CH2:24][C:25]([CH3:32])([CH3:31])[NH:26][C:27]([CH3:30])([CH3:29])[CH2:28]3)[N:9]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 375244-Amino-2,2,6,6-tetramethylpiperidineHCID 57936333HCID 57936333, compound

Product 1

HCID 57936130HCID 57936130, compound

Procedure

3-[5-(2-Methanesulfinyl-pyrimidin-4-yl)-pyridin-2-yl]-1,1-dimethyl-prop-2-ynylamine (500 mg, 1.76 mmol) and 4-amino-2,2,6,6-tetramethylpiperidine (0.61 ml, 3.54 mmol) were heated to 120° C. for 1 hour and the reaction mixture purified directly by chromatography on silicagel (TBME/MeOH/ammonia:95/4.5/0.5) to give the title compound as yellow crystals.

Workup

  1. customthe reaction mixture purified directly by chromatography on silicagel (TBME/MeOH/ammonia:95/4.5/0.5)

Sources & evidence

ORD record
ord-4c42bbf545ef4151953c61c747ad57d2
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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