4-Amino-2,2,6,6-tetramethylpiperidine → HCID 57936130, compound

Participants

Reaction Steps

3-[5-(2-Methanesulfinyl-pyrimidin-4-yl)-pyridin-2-yl]-1,1-dimethyl-prop-2-ynylamine (500 mg, 1.76 mmol) and 4-amino-2,2,6,6-tetramethylpiperidine (0.61 ml, 3.54 mmol) were heated to 120° C. for 1 hour and the reaction mixture purified directly by chromatography on silicagel (TBME/MeOH/ammonia:95/4.5/0.5) to give the title compound as yellow crystals.

Provenance & Evidence