4-(2-Carboxyethyl)benzeneboronic acid → 3-{4-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propionic acid

HRID 1435000Notes

Reaction equation

HRID 1435000 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[NH:12][C:11]([CH3:18])([CH3:17])[CH2:10]2)[N:3]=1.[C:19]([CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27](B(O)O)=[CH:26][CH:25]=1)([OH:21])=[O:20]>>[CH3:15][C:13]1([CH3:16])[CH2:14][CH:9]([NH:8][C:4]2[N:3]=[C:2]([C:27]3[CH:28]=[CH:29][C:24]([CH2:23][CH2:22][C:19]([OH:21])=[O:20])=[CH:25][CH:26]=3)[CH:7]=[CH:6][N:5]=2)[CH2:10][C:11]([CH3:18])([CH3:17])[NH:12]1

Participants

3

Reactant 2

HCID 38634844-(2-Carboxyethyl)benzeneboronic acidHCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine

Product 1

HCID 579362343-{4-[2-(2,2,6,6-Tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propionic acid

Procedure

The title compound was prepared from (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine and 4-(2-carboxyethyl)phenylboronic acid according to Method C (Example 178). Yield: 1.4 g (100%).

Sources & evidence

ORD record
ord-673937be3b3447019c0a4b2c8c9f4445
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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