4-Toluenesulfonyl chloride → Toluene-4-sulfonic acid 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propyl ester

HRID 1435004Notes

Reaction equation

HRID 1435004 reaction equation
[CH3:1][C:2]1([CH3:27])[CH2:7][CH:6]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][OH:24])=[CH:17][CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH2:5][C:4]([CH3:26])([CH3:25])[NH:3]1.[C:28]1([CH3:38])[CH:33]=[CH:32][C:31]([S:34](Cl)(=[O:36])=[O:35])=[CH:30][CH:29]=1>N1C=CC=CC=1>[CH3:25][C:4]1([CH3:26])[CH2:5][CH:6]([NH:8][C:9]2[N:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([CH2:21][CH2:22][CH2:23][O:24][S:34]([C:31]4[CH:32]=[CH:33][C:28]([CH3:38])=[CH:29][CH:30]=4)(=[O:36])=[O:35])=[CH:17][CH:16]=3)[CH:12]=[CH:11][N:10]=2)[CH2:7][C:2]([CH3:27])([CH3:1])[NH:3]1

Participants

4

Reactant 2

HCID 73974-Toluenesulfonyl chlorideHCID 57936185HCID 57936185, compound

Product 1

HCID 57936242Toluene-4-sulfonic acid 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propyl ester

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound was prepared from 3-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-propan-1-ol (Example 189) and p-toluenesulfonyl chloride in pyridine. Yield: 140 mg (45%).

Sources & evidence

ORD record
ord-4614402e4fa549288a1dba80783bad85
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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