反应详情

温度

60 °C

To a solution of 4-{4-[2-(2,2,6,6-tetramethyl-piperidin-4-ylamino)-pyrimidin-4-yl]-phenyl}-butyronitrile (Example 192) (37 mg, 0.10 mmol) in 2 ml THF was added LAH (1 M in THF, 294 μl, 0.294 mmol). The reaction mixture was stirred at 60° C. for 2 hours. The mixture was quenched with 0.5 ml aqueous sodium sulfate, followed by 2N-NaOH (pH 11). Extraction with EtOAc and purification using preparative HPLC gave the title compound. Yield: 16 mg (43%).

1. customThe mixture was quenched with 0.5 ml aqueous sodium sulfate
2. extractionExtraction
3. customwith EtOAc and purification