(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amine → HCID 57936296, compound

HRID 1435031Notes

Reaction equation

HRID 1435031 reaction equation
C([Si](C)(C)[N:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([CH2:15][CH:16]([NH:18]C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH3:17])[CH:13]=2)[CH:8]=[CH:7]1)(C)(C)C.Cl[C:41]1[CH:46]=[CH:45][N:44]=[C:43]([NH:47][CH:48]2[CH2:53][C:52]([CH3:55])([CH3:54])[NH:51][C:50]([CH3:57])([CH3:56])[CH2:49]2)[N:42]=1>>[NH2:18][CH:16]([CH3:17])[CH2:15][C:12]1[CH:13]=[C:14]2[C:9]([C:8]([C:45]3[CH:46]=[CH:41][N:42]=[C:43]([NH:47][CH:48]4[CH2:53][C:52]([CH3:55])([CH3:54])[NH:51][C:50]([CH3:57])([CH3:56])[CH2:49]4)[N:44]=3)=[CH:7][NH:6]2)=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 57936167(4-Chloro-pyrimidin-2-yl)(2,2,6,6-tetramethyl-piperidin-4-yl)-amineHCID 69061243HCID 69061243, compound

Product 1

HCID 57936296HCID 57936296, compound

Procedure

The title compound was prepared as described in Example 215, starting from {2-[1-(tert-butyl-dimethyl-silanyl)-1H-indol-6-yl]-1-methyl-ethyl}-trityl-amine (prepared by trityl and TBDMS protection of 2-(1H-Indol-6-yl)-1-methyl-ethylamine) and (4-chloro-pyrimidin-2-yl)-(2,2,6,6-tetramethyl-piperidin-4-yl)-amine, followed by in situ removal of the protecting groups with 2N-HCl. Yield: 406 mg (31%).

Workup

  1. customfollowed by in situ removal of the protecting groups with 2N-HCl

Sources & evidence

ORD record
ord-b1e73572c6154c068a9bedb44a63ca24
Source dataset
uspto-grants-2009_11
Patent number
US07615562B2

Reaction notes

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