HCID 57937828, compound → HCID 57937836, compound

HRID 1435074Notes

Reaction equation

[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:28])[NH2:27])=[CH:22][C:21]=2[CH3:29])=[CH:16][CH:15]=1)[CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])([CH3:4])([CH3:3])[CH3:2]>COC(OC)N(C)C>[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:28])[N:27]=[CH:6][N:7]([CH3:13])[CH3:8])=[CH:22][C:21]=2[CH3:29])=[CH:18][CH:19]=1)[CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])([CH3:2])([CH3:3])[CH3:4]

Participants

Conditions

Temperature: 120 °C

Procedure

(4′-Carbamoyl-2′-methyl-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-4-b: 200.0 mg, 0.487 mmol) was dissolved in dimethylformamide dimethylacetal (5.0 ml) and heated to 120° C. After 2 hours, the reaction mixture was cooled to room temperature and the volatiles removed under reduced pressure. The resulting residue was used in the next reaction without further purification.

Workup

temperaturethe reaction mixture was cooled to room temperature
customthe volatiles removed under reduced pressure
customThe resulting residue was used in the next reaction without further purification

Sources & evidence

ORD record: ord-2a3052c6c632413bbb23dd20199e710c
Source dataset: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07615651B2

Reaction notes

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