HCID 57937834, compound → HCID 57937838, compound

HRID 1435077Notes

Reaction equation

HRID 1435077 reaction equation
[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:25][CH2:26][CH:27]([CH3:29])[CH3:28])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-])=O)=[CH:17][CH:16]=2)=[C:11]([CH3:24])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=2)=[C:11]([CH3:24])[CH:10]=1)[CH2:25][CH2:26][CH:27]([CH3:29])[CH3:28])([CH3:2])([CH3:3])[CH3:4]

Participants

5

Reactant 2

HCID 57937834HCID 57937834, compoundHCID 178418361HCID 178418361, compound2×

Product 1

HCID 57937838HCID 57937838, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

(3-Methyl-butyl)-(2-methyl-4′-nitro-biphenyl-4-ylmethyl)-carbamic acid tert-butyl ester (I-9a: 0.150 mg, 0.364 mmol) in methanol (12.1 ml) was hydrogenated employing an H-cube apparatus (atmospheric pressure, flow rate=1 mL/min, hydrogen level=full hydrogen, temperature=35° C.). The reaction mixture was allowed to proceed through a palladium on carbon cartridge and the contents collected and concentrated under reduced pressure. The resulting title compound (I-8b) was carried on to the next reaction without further purification.

Workup

  1. customthe contents collected
  2. concentrationconcentrated under reduced pressure
  3. customThe resulting title compound (I-8b) was carried on to the next reaction without further purification

Sources & evidence

ORD record
ord-87af8525bea6400fb652d90135bcb594
Source dataset
uspto-grants-2009_11
Patent number
US07615651B2

Reaction notes

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