Hydrochloric Acid → HCID 131727753, compound

Participants

Reaction Steps

(4′-Carbamoyl-2′-methyl-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-4b: 8.0 g, 23 mmol) was dissolved in methanol (50 mL) and treated with 4M hydrogen chloride in dioxane (10 mL). After stirring for 12 hours, the volatiles were removed under reduced pressure and the resulting solid was titrated with hexanes and isolated by filtration to provide 7.1 g the title compound (E4-02) as a colorless solid.

Provenance & Evidence