Hydrochloric Acid → HCID 131727753, compound

HRID 1435083Notes

Reaction equation

HRID 1435083 reaction equation
C(OC(=O)[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][C:23]([C:26](=[O:28])[NH2:27])=[CH:22][C:21]=2[CH3:29])=[CH:16][CH:15]=1)[CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:31]>CO.O1CCOCC1>[Cl-:31].[C:26]([C:23]1[CH:24]=[CH:25][C:20]([C:17]2[CH:18]=[CH:19][C:14]([CH2:13][NH2+:7][CH2:8][CH2:9][CH:10]([CH3:11])[CH3:12])=[CH:15][CH:16]=2)=[C:21]([CH3:29])[CH:22]=1)(=[O:28])[NH2:27].[NH4+:7].[Cl-:31]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57937828HCID 57937828, compound

Product 1

HCID 131727753HCID 131727753, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

(4′-Carbamoyl-2′-methyl-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-4b: 8.0 g, 23 mmol) was dissolved in methanol (50 mL) and treated with 4M hydrogen chloride in dioxane (10 mL). After stirring for 12 hours, the volatiles were removed under reduced pressure and the resulting solid was titrated with hexanes and isolated by filtration to provide 7.1 g the title compound (E4-02) as a colorless solid.

Workup

  1. customthe volatiles were removed under reduced pressure
  2. customisolated by filtration

Sources & evidence

ORD record
ord-81d28f22ff264122b6bbc9e12ef469fb
Source dataset
uspto-grants-2009_11
Patent number
US07615651B2

Reaction notes

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