Hydrochloric Acid → HCID 86621477, compound

Participants

Reaction Steps

[(3′-Carbamoyl-2-fluoro-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-5d): 0.180 g, 0.434 mmol) was dissolved in dichloromethane (10 ml) and treated with 1 ml of a 4M hydrogen chloride solution in dioxane. After 1 hour, the reaction mixture was concentrated under reduced pressure to provide a solid that was titrated with hexanes to afford the title product (E5-01) after filtration.

Provenance & Evidence