Hydrochloric Acid → HCID 86621477, compound

HRID 1435084Notes

Reaction equation

HRID 1435084 reaction equation
C(OC(=O)[N:7]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([C:26](=[O:28])[NH2:27])[CH:21]=2)=[C:16]([F:29])[CH:15]=1)[CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])(C)(C)C.[ClH:31]>ClCCl.O1CCOCC1>[Cl-:31].[C:26]([C:22]1[CH:21]=[C:20]([C:17]2[CH:18]=[CH:19][C:14]([CH2:13][NH2+:7][CH2:8][CH2:9][CH:10]([CH3:11])[CH3:12])=[CH:15][C:16]=2[F:29])[CH:25]=[CH:24][CH:23]=1)(=[O:28])[NH2:27]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57937843HCID 57937843, compound

Product 1

HCID 86621477HCID 86621477, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

[(3′-Carbamoyl-2-fluoro-biphenyl-4-ylmethyl)-(3-methyl-butyl)-carbamic acid tert-butyl ester (I-5d): 0.180 g, 0.434 mmol) was dissolved in dichloromethane (10 ml) and treated with 1 ml of a 4M hydrogen chloride solution in dioxane. After 1 hour, the reaction mixture was concentrated under reduced pressure to provide a solid that was titrated with hexanes to afford the title product (E5-01) after filtration.

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customto provide a solid

Sources & evidence

ORD record
ord-3b4d42ae902c4438877680f92a08c95f
Source dataset
uspto-grants-2009_11
Patent number
US07615651B2

Reaction notes

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