Propanoic acid, 2-bromo-2-methyl-, ethyl ester → HCID 57866374, compound

HRID 1435087Notes

Reaction equation

HRID 1435087 reaction equation
Br[C:2]([CH3:9])([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH2:10]([SH:13])[CH:11]=[CH2:12].[OH-].[K+]>C(O)C>[CH2:6]([O:5][C:3](=[O:4])[C:2]([S:13][CH2:10][CH:11]=[CH2:12])([CH3:9])[CH3:8])[CH3:7]

Participants

5

Reactant 3

HCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 13367Allyl MercaptanHCID 14797Potassium Hydroxide

Product 1

HCID 57866374HCID 57866374, compoundYield 35%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-bromoisobutyrate (40.0 g, 0.205 mole), allyl mercaptan (16.8 g, 0.0226 mole), potassium hydroxide (14.4 g, 0.226 mole), ethyl alcohol (100 g) were combined and reaction mixture was refluxed for six hours prior to quenching. Crude yield: 79.3%; Distilled yield: 35.0%.

Workup

  1. customreaction mixture
  2. temperaturewas refluxed for six hours
  3. customto quenching
  4. distillationDistilled yield: 35.0%

Sources & evidence

ORD record
ord-03b282c9275c4e23a9c3f68c94fdbdd8
Source dataset
uspto-grants-2009_11
Patent number
US07615661B2

Reaction notes

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