2-Propanethiol → HCID 22627680, compound

HRID 1435092Notes

Reaction equation

HRID 1435092 reaction equation
Br[C:2]([CH3:9])([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[CH3:10][CH:11]([SH:13])[CH3:12].[OH-].[K+]>C(O)C>[CH2:6]([O:5][C:3](=[O:4])[C:2]([S:13][CH:11]([CH3:12])[CH3:10])([CH3:9])[CH3:8])[CH3:7]

Participants

5

Reactant 3

HCID 63642-PropanethiolHCID 11745Propanoic acid, 2-bromo-2-methyl-, ethyl esterHCID 14797Potassium Hydroxide

Product 1

HCID 22627680HCID 22627680, compoundYield 61.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-bromoisobutyrate (100 g, 0.513 mole), 2-propanethiol (42.95 g, 0.564 mole), potassium hydroxide (36.0 g, 0.564 mole), ethyl alcohol (200 g) were combined and reaction mixture was refluxed for three hours prior to quenching. Crude yield: 74.7%, distilled yield: 61.7%.

Workup

  1. customreaction mixture
  2. temperaturewas refluxed for three hours
  3. customto quenching
  4. distillationCrude yield: 74.7%, distilled yield: 61.7%

Sources & evidence

ORD record
ord-7380a274bc4f4f809cc00ae297b67d6b
Source dataset
uspto-grants-2009_11
Patent number
US07615661B2

Reaction notes

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