HRID1435096

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)OCc1ccccc1)c1ccccc1

HCID57936733

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)c1ccccc1

HCID57936728

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

23.4 g (23.8 mmol) (Z-Phg-D-Trp-Lys(BOC)-OMe) are dissolved in 260 ml methanol, 2.6 g Pd/C 10% added and hydrogenated at RT and normal pressure. After 3 hours the catalyst is filtered off and the filtrate evaporated at 30°: white solid. HPLC 95.9% b.a. (17.6 min).

WORKUP

后处理

customhydrogenated at RT
filtrationAfter 3 hours the catalyst is filtered off
customthe filtrate evaporated at 30°
custom(17.6 min)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f19814df138b43eeb7f30244518c9ebc
来源数据集: uspto-grants-2009_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07615609B2
来源说明: uspto-grants-2009_11

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:9]([NH:11][C@@H:12]([C:23]([NH:25][C@H:26]([C:39]([O:41][CH3:42])=[O:40])[CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1)=[O:10])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CO.[Pd]>[NH2:1][C@H:2]([C:9]([NH:11][C@@H:12]([C:23]([NH:25][C@H:26]([C:39]([O:41][CH3:42])=[O:40])[CH2:27][CH2:28][CH2:29][CH2:30][NH:31][C:32]([O:34][C:35]([CH3:37])([CH3:38])[CH3:36])=[O:33])=[O:24])[CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[NH:16][CH:15]=1)=[O:10])[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1