1-Amino-2-propanol → HCID 58777660, compound

HRID 1435303Notes

Reaction equation

HRID 1435303 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][N:23]([S:26]([CH2:29][CH2:30][CH2:31][CH2:32]Cl)(=[O:28])=[O:27])[CH2:22][CH2:21]2)[N:3]=1.[NH2:34][CH2:35][CH:36]([OH:38])[CH3:37]>>[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[CH:13]=[CH:12][C:11]=2[O:17][CH3:18])=[O:9])=[CH:6][N:5]=[C:4]([NH:19][CH:20]2[CH2:25][CH2:24][N:23]([S:26]([CH2:29][CH2:30][CH2:31][CH2:32][NH:34][CH2:35][CH:36]([OH:38])[CH3:37])(=[O:28])=[O:27])[CH2:22][CH2:21]2)[N:3]=1

Participants

3

Reactant 2

HCID 41-Amino-2-propanolHCID 58777553HCID 58777553, compound

Product 1

HCID 58777660HCID 58777660, compound

Procedure

The compound was prepared from [4-amino-2-[1-(4-chloro-butane-1-sulfonyl)-piperidin-4-ylamino]-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone (Example 255) and 1-amino-2-propanol (Eastman Kodak) in an analogous manner as described in Example 227. HR-MS (ES, m/z) calculated for C24H35N6O5SF [(M+H)+]539.2451, observed 539.2447.

Sources & evidence

ORD record
ord-a215ed2d210f42929c23bdf959b1b472
Source dataset
uspto-grants-2009_11
Patent number
US07615634B2

Reaction notes

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