反应详情

The amine (44 mg, 0.22 mmol, Example 305) and chloropyrimidine (55 mg, 0.18 mmol, Example 289) were dissolved in ethanol (5 mL). To the stirred mixture at reflux, diisopropylethylamine (64 uL, Aldrich) was added and the mixture was refluxed for 20 hours. The solvent was removed and the residue was purified by HPLC (10-60%, acetonitrile/water) to give a white solid, 25 mg, 30%. MS (ES) MH+=458.

1. temperatureTo the stirred mixture at reflux
2. temperaturethe mixture was refluxed for 20 hours
3. customThe solvent was removed
4. customthe residue was purified by HPLC (10-60%, acetonitrile/water)
5. customto give a white solid, 25 mg, 30%