Potassium hydroxy sulfite → HCID 57937354, compound

HRID 1435471Notes

Reaction equation

HRID 1435471 reaction equation
[OH:1]OS([O-])=O.[K+].[CH3:7][C:8]([C:12]1[N:16]([CH2:17][CH:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[C:15]2[CH:24]=[CH:25][C:26]([S:28]([N:31]3[CH:35]=[CH:34][C:33]([CH:36]=[O:37])=[CH:32]3)(=[O:30])=[O:29])=[CH:27][C:14]=2[N:13]=1)([CH3:11])[CH2:9][CH3:10]>CN(C=O)C>[CH3:11][C:8]([C:12]1[N:16]([CH2:17][CH:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)[C:15]2[CH:24]=[CH:25][C:26]([S:28]([N:31]3[CH:35]=[CH:34][C:33]([C:36]([OH:1])=[O:37])=[CH:32]3)(=[O:30])=[O:29])=[CH:27][C:14]=2[N:13]=1)([CH3:7])[CH2:9][CH3:10]

Participants

4

Reactant 2

HCID 23707502Potassium hydroxy sulfiteHCID 579373651-{[2-(1,1-dimethylpropyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]sulfonyl}-1H-pyrrole-3-carbaldehyde

Product 1

HCID 57937354HCID 57937354, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Oxone (148 mg, 0.24 mmol) was added to a solution of 1-{[2-(1,1-dimethylpropyl)-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]sulfonyl}-1H-pyrrole-3-carbaldehyde (89 mg, 0.20 mmol) in DMF (8 mL). The resulting mixture was stirred overnight at room temperature and used directly for step A. MS (ESI) (M+H)+=460.06.

Sources & evidence

ORD record
ord-fb854e6229cd47cea39449f0d43e1c9a
Source dataset
uspto-grants-2009_11
Patent number
US07615642B2

Reaction notes

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