HCID 57441096, compound → HCID 57723216, compound

HRID 1435530Notes

Reaction equation

HRID 1435530 reaction equation
[F:1][C:2]1[CH2:7][CH2:6][CH:5]([CH2:8][NH:9][C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17](=[O:19])[CH3:18])=[CH:12][C:11]=2[N+:20]([O-])=O)[CH2:4][CH:3]=1>CCOC(C)=O.[Pd]>[NH2:20][C:11]1[CH:12]=[C:13]([NH:16][C:17](=[O:19])[CH3:18])[CH:14]=[CH:15][C:10]=1[NH:9][CH2:8][CH:5]1[CH2:4][CH2:3][CH:2]([F:1])[CH2:7][CH2:6]1

Participants

4

Reactant 1

HCID 57441096HCID 57441096, compound

Product 1

HCID 57723216HCID 57723216, compound

Reagents, catalysts & solvents 2

HCID 8857Ethyl AcetateSolventHCID 23938PalladiumSolvent

Procedure

N-(4-{[(4-Fluorocyclohex-3-en-1-yl)methyl]amino}-3-nitrophenyl)acetamide (340 mg, 1.11 mmol) was dissolved in 25 mL of EtOAc containing a catalytic amount of 10% Pd/C. The solution was shaken under H2 atmosphere (40 psi) using a Parr hydrogenation apparatus at rt for 48 h. The solution was filtered through Celite and the solvent was evaporated. Yield: 308 mg (99%). MS (ESI) (M+H)−=279.95.

Workup

  1. customat rt
  2. customfor 48 h
  3. filtrationThe solution was filtered through Celite
  4. customthe solvent was evaporated

Sources & evidence

ORD record
ord-3025b44e35fa43b38fabf713daf6bddd
Source dataset
uspto-grants-2009_11
Patent number
US07615642B2

Reaction notes

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