Diisopropylethylamine → HCID 57937316, 화합물

HRID 1435536노트

반응식

HRID 1435536 반응식
[C:1]([C:5]1[N:9]([CH2:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:8]2[CH:17]=[CH:18][C:19]([S:21](Cl)(=[O:23])=[O:22])=[CH:20][C:7]=2[N:6]=1)([CH3:4])([CH3:3])[CH3:2].Cl.[NH:26]1[CH2:29][CH:28]([CH2:30][C:31]([OH:33])=[O:32])[CH2:27]1.CCN(C(C)C)C(C)C>CN(C=O)C>[C:1]([C:5]1[N:9]([CH2:10][CH:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:8]2[CH:17]=[CH:18][C:19]([S:21]([N:26]3[CH2:29][CH:28]([CH2:30][C:31]([OH:33])=[O:32])[CH2:27]3)(=[O:23])=[O:22])=[CH:20][C:7]=2[N:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 579372982-tert-Butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazole-5-sulfonyl chlorideHCID 666150163-Azetidineacetic acid hydrochloride

생성물 1

HCID 57937316HCID 57937316, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Following the same procedure in Example 1, Step A, using 2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazole-5-sulfonyl chloride (700 mg, 1.9 mmol), azetidin-3-ylacetic acid hydrochloride (495 mg, 3.3 mmol) and DIPEA (4 mL) in DMF (20 mL), provided the title compound as a crude product (600 mg, 70%), which was used directly in Step A.

출처 및 근거

ORD 기록
ord-0488bf721e154b7cb9f0f048d97e2c52
출처 데이터셋
uspto-grants-2009_11
특허 번호
US07615642B2

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