Ethylamine → N-ethyl-5-methyl-1H-pyrazole-4-carboxamide

HRID 1435541Notes

Reaction equation

HRID 1435541 reaction equation
[CH3:1][C:2]1[C:6]([C:7]([OH:9])=O)=[CH:5][NH:4][N:3]=1.[CH2:10]([NH2:12])[CH3:11]>>[CH2:10]([NH:12][C:7]([C:6]1[C:2]([CH3:1])=[N:3][NH:4][CH:5]=1)=[O:9])[CH3:11]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 5576005-methyl-1H-pyrazole-4-carboxylic acid

Product 1

HCID 178464939N-ethyl-5-methyl-1H-pyrazole-4-carboxamideYield 100%

Procedure

Following the same procedure in Example 29 (Steps B and C in Method B), using 3-methyl-1H-pyrazole-4-carboxylic acid (252 mg, 2.0 mmol) and ethylamine (225 mg, 5.0 mmol), provided the desired crude compound (306 mg, 100%), which was used in Step A directly.

Sources & evidence

ORD record
ord-354feb8571ca4f4cacd1d39c44c04773
Source dataset
uspto-grants-2009_11
Patent number
US07615642B2

Reaction notes

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