Ethylamine → HCID 43582334, compound

HRID 1435545Notes

Reaction equation

HRID 1435545 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6](Cl)=[O:7])[CH:3]=[N:2]1.[CH2:9]([NH2:11])[CH3:10].C(N(CC)CC)C>C(Cl)Cl>[CH2:9]([NH:11][C:6]([C:4]1[CH:3]=[N:2][NH:1][CH:5]=1)=[O:7])[CH3:10]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 8471TriethylamineHCID 22228227HCID 22228227, compound

Product 1

HCID 43582334HCID 43582334, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following the same procedure in Example 28 (Step C of Method B), using 1H-pyrazole-4-carbonyl chloride (0.47 g, 3.6 mmol), ethylamine (3.0 mL, 2.0 M in THF, 6.0 mmol) and triethylamine (1.01 g, 1.39 mL, 10 mmol) in CH2Cl2 (15 mL), provided the title compound as a white solid. Yield: 0.49 g (97% yield). 1H NMR (400 MHz, METHANOL-D4) δ 1.18 (t, J=7.23 Hz, 3 H) 3.34 (q, J=7.23 Hz, 2 H) 7.92 (s, 1 H) 8.09 (s, 1 H)

Sources & evidence

ORD record
ord-df0ee9010f554386843e7174f42f1d98
Source dataset
uspto-grants-2009_11
Patent number
US07615642B2

Reaction notes

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