HCID 62588378, compound → HCID 86618326, compound

HRID 1435573Notes

Reaction equation

HRID 1435573 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:15])[CH2:11][CH2:12][O:13][CH3:14])[CH:6]=[CH:7][CH:8]=1>CC(C)=O.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[CH:4]=[C:5]([NH:9][C:10](=[O:15])[CH2:11][CH2:12][O:13][CH3:14])[CH:6]=[CH:7][CH:8]=1)=[O:1]

Participants

4

Reactant 1

HCID 62588378HCID 62588378, compound

Product 1

HCID 86618326HCID 86618326, compound

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 180AcetoneSolvent

Procedure

The above 1.26 g N-(3-Hydroxymethyl-phenyl)-3-methoxy-propionamide were dissolved in 50 ml acetone, 12.60 g manganese dioxide were added and the mixture stirred at room temperature over night. The mixture was filtered and the filtrate evaporated and further purified by chromatography on silica in ethyl acetate/heptane mixtures. Yield 0.77 g of the title compound as a colourless oil.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate evaporated
  3. customfurther purified by chromatography on silica in ethyl acetate/heptane mixtures

Sources & evidence

ORD record
ord-9e01e3f8e78246debaa441063c6b3344
Source dataset
uspto-grants-2009_11
Patent number
US07618964B2

Reaction notes

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