Water → 91340-30-6

HRID 1435604Notes

Reaction equation

HRID 1435604 reaction equation
C(OC([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][N:8]([CH:13]2[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]2)[C:7]1=[O:19])=O)C.O>[N+](C)([O-])=O>[CH:13]1([N:8]2[CH2:9][CH2:10][C:11](=[O:12])[CH2:6][C:7]2=[O:19])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 962WaterHCID 68581585HCID 68581585, compound

Product 1

HCID 1070301191340-30-6

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

1-Cyclohexyl-2,4-dioxo-piperidine-3-carboxylic acid ethyl ester (3.1 g, 11.6 mmol) was heated with water (0.25 ml, 13.9 mmol) in nitromethane (30 ml) at 95° C. for 1 hour. The solution was concentrated to give an off-white solid weighing 2.3 g (93%). A sample was recrystallised from toluene.

Workup

  1. concentrationThe solution was concentrated
  2. customto give an off-white solid
  3. customA sample was recrystallised from toluene

Sources & evidence

ORD record
ord-0e1ebcfde33a4ed691a5c78719ee516b
Source dataset
uspto-grants-2009_11
Patent number
US07618966B2

Reaction notes

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