2-Chlorobenzenesulfonyl chloride → HCID 10133173, compound

HRID 1435610Notes

Reaction equation

HRID 1435610 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20](Cl)(=[O:22])=[O:21]>>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10133173HCID 10133173, compoundYield 22%

Procedure

The tide compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-chlorobenzenesulfonyl chloride according to METHOD A, giving 0.65 g (22%) of a pink solid after recrystallization from methanol: MS (Ionspray, [M+H]+) m/z 361; Anal. Calcd (found) for C13H13ClN2O4S2: C, 43.3 (43.2)%, H, 3.6 (3.5)%, N, 7.8 (7.6)%.

Sources & evidence

ORD record
ord-237ca8a14b704446bc7cc909af22885b
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…