m-Bromobenzenesulphonyl chloride → HCID 10158135, compound

HRID 1435612Notes

Reaction equation

HRID 1435612 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Br:13][C:14]1[CH:15]=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>>[Br:13][C:14]1[CH:15]=[C:16]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10158135HCID 10158135, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3-bromobenzenesulfonyl chloride according to METHOD A, using a Quest 210 apparatus and at 30° C., giving 1.16 g (27%) of an off-white solid: mp 155° C.; MS (Ionspray, [M+H]+) m/z 405; Anal. Calcd (found) for C13H13BrN2O4S2: C, 38.5 (38.4)%, H, 3.2 (3.0)%, N, 6.9 (6.6)%.

Sources & evidence

ORD record
ord-e13e4d5e02da4c0e85b7f4231eb67bbb
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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