4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl (2-{[(3-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435615Notes

Reaction equation

HRID 1435615 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][C:14]1[CH:15]=[C:16]([S:20](Cl)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1>>[CH3:13][C:14]1[CH:15]=[C:16]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27345953-Methylbenzenesulphonyl chloride

Product 1

HCID 10268844Ethyl (2-{[(3-methylphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 3-methylbenzenesulfonyl chloride according to METHOD A, giving 0.51 g (75%) of a pink powder: MS (electrospray, [M−H]−) m/z 339.2.

Sources & evidence

ORD record
ord-2d3f90e51fe74c3cb840fe3441bc3666
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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