o-Toluenesulfonyl chloride → HCID 10268845, compound

HRID 1435620Notes

Reaction equation

HRID 1435620 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH3:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20](Cl)(=[O:22])=[O:21]>>[CH3:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 8623o-Toluenesulfonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10268845HCID 10268845, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-methylbenzenesulfonyl chloride according to METHOD A, giving 0.22 g (32%) of a pink powder: 1H NMR (CDCl3) δ: 1.3 (3H, t), 2.5 (3H, s), 3.9 (2H, s), 4.2 (2H, q), 6.4 (1H, s), 7.8-7.2 (3H, m), 8.1 (1H, t).

Sources & evidence

ORD record
ord-2e8288f3734445f6876a17d881e018d2
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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