4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10294025, compound

HRID 1435621Notes

Reaction equation

HRID 1435621 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[F:13][C:14]([F:26])([F:25])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21](Cl)(=[O:23])=[O:22]>>[F:26][C:14]([F:13])([F:25])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[S:21]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:22])=[O:23]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 1366162-Trifluoromethylbenzenesulphonyl chloride

Product 1

HCID 10294025HCID 10294025, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-trifluoromethylbenzenesulfonyl chloride according to METHOD A, giving 0.13 g (31%) of a red solid after recrystallization from acetone/ether/petroleum ether: mp 171° C.; MS (Ionspray, [M+H]+) m/z 395; Anal. Calcd (found) for C14H13F3N2O4S2: C, 42.6 (43.0)%, H, 3.3 (2.9)%, N, 7.1 (6.9)%.

Sources & evidence

ORD record
ord-f6989fc297d641d3bd542162b4793d93
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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