4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10294025, compound

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Reaction Steps

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2-trifluoromethylbenzenesulfonyl chloride according to METHOD A, giving 0.13 g (31%) of a red solid after recrystallization from acetone/ether/petroleum ether: mp 171° C.; MS (Ionspray, [M+H]+) m/z 395; Anal. Calcd (found) for C14H13F3N2O4S2: C, 42.6 (43.0)%, H, 3.3 (2.9)%, N, 7.1 (6.9)%.

Provenance & Evidence