4-Thiazoleacetic acid, 2-amino-, ethyl ester → HCID 10112152, compound

HRID 1435626Notes

Reaction equation

HRID 1435626 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22]([NH:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chloride

Product 1

HCID 10112152HCID 10112152, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (34.6 mg) with purity >90%: LCMS (pos) m/z 409.0, 411.0; HRMS m/z 407.9753 (calc. of monoisotopic mass for C14H14Cl2N2O4S2 gives 407.9772).

Sources & evidence

ORD record
ord-af91216a7b364ebf8fd9f7e8c9f6fc0b
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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