4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl (2-{[(4-butoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435635Notes

Reaction equation

HRID 1435635 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[CH2:13]([O:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1)[CH2:14][CH2:15][CH3:16]>>[CH2:13]([O:17][C:18]1[CH:23]=[CH:22][C:21]([S:24]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:26])=[O:25])=[CH:20][CH:19]=1)[CH2:14][CH2:15][CH3:16]

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 5179904-Butoxybenzenesulfonyl Chloride

Product 1

HCID 10294305Ethyl (2-{[(4-butoxyphenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-n-butoxybenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (11.8 mg) with purity >90%. LCMS (pos) m/z 399.2.

Sources & evidence

ORD record
ord-16572dedbf134a5f90677bc98b2f1322
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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