4-Chloro-2-methylbenzenesulphonyl chloride → HCID 10270797, compound

HRID 1435636Notes

Reaction equation

HRID 1435636 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20](Cl)(=[O:22])=[O:21])=[C:16]([CH3:24])[CH:15]=1>>[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([S:20]([NH:1][C:2]2[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:22])=[O:21])=[C:16]([CH3:24])[CH:15]=1

Participants

3

Reactant 2

HCID 417484-Chloro-2-methylbenzenesulphonyl chlorideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 10270797HCID 10270797, compound

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 4-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (9.4 mg) with purity >90%. LCMS (pos) m/z 375.2.

Sources & evidence

ORD record
ord-e4dd90270fe2456ababdbc42fc47e7ee
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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