4-Thiazoleacetic acid, 2-amino-, ethyl ester → Ethyl [2-({[5-(3-isoxazolyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate

HRID 1435678Notes

Reaction equation

HRID 1435678 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[O:13]1[CH:17]=[CH:16][C:15]([C:18]2[S:22][C:21]([S:23](Cl)(=[O:25])=[O:24])=[CH:20][CH:19]=2)=[N:14]1>>[O:13]1[CH:17]=[CH:16][C:15]([C:18]2[S:22][C:21]([S:23]([NH:1][C:2]3[S:3][CH:4]=[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=3)(=[O:25])=[O:24])=[CH:20][CH:19]=2)=[N:14]1

Participants

3

Reactant 2

HCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl esterHCID 27971805-(Isoxazol-3-yl)thiophene-2-sulfonyl chloride

Product 1

HCID 10200946Ethyl [2-({[5-(3-isoxazolyl)-2-thienyl]sulfonyl}amino)-1,3-thiazol-4-yl]acetate

Procedure

The title compound was prepared from ethyl 2-amino-4-thiazolylacetate and 5-isoxazol-3-ylthiophene-2-sulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (15.9 mg) with purity >90%. MS (pos) m/z 400.3.

Sources & evidence

ORD record
ord-76bb9397247048ca8a56e913c8d3a742
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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