2,4,6-Trichlorobenzenesulfonyl chloride → Ethyl oxo(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

HRID 1435684Notes

Reaction equation

HRID 1435684 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[Cl:14][C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([Cl:22])[C:16]=1[S:23](Cl)(=[O:25])=[O:24]>>[O:13]=[C:7]([C:5]1[N:6]=[C:2]([NH:1][S:23]([C:16]2[C:17]([Cl:22])=[CH:18][C:19]([Cl:21])=[CH:20][C:15]=2[Cl:14])(=[O:25])=[O:24])[S:3][CH:4]=1)[C:8]([O:10][CH2:11][CH3:12])=[O:9]

Participants

3

Reactant 2

HCID 5213352,4,6-Trichlorobenzenesulfonyl chlorideHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 10138353Ethyl oxo(2-{[(2,4,6-trichlorophenyl)sulfonyl]amino}-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from ethyl (2-amino-4-thiazolyl)glyoxylate and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (18.3 mg) with purity >80%. LCMS (pos) m/z 445.0.

Sources & evidence

ORD record
ord-a68f2aff9dae4daa92bf02385b1de063
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

Loading…