(1,1'-Biphenyl)-4-sulphonyl chloride → Ethyl {2-[([1,1'-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}(oxo)acetate

HRID 1435685Notes

Reaction equation

HRID 1435685 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=1.[C:14]1([C:20]2[CH:25]=[CH:24][C:23]([S:26](Cl)(=[O:28])=[O:27])=[CH:22][CH:21]=2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:20]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:25]=[CH:24][C:23]([S:26]([NH:1][C:2]2[S:3][CH:4]=[C:5]([C:7](=[O:13])[C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:6]=2)(=[O:28])=[O:27])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 4356513Ethyl 2-(2-Amino-4-thiazolyl)-2-oxoacetate

Product 1

HCID 10295384Ethyl {2-[([1,1'-biphenyl]-4-ylsulfonyl)amino]-1,3-thiazol-4-yl}(oxo)acetate

Procedure

The title compound was prepared from ethyl (2-amino-4-thiazolyl)glyoxylate and 4-phenylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (28.2 mg) with purity >80%. LCMS (pos) m/z 417.0.

Sources & evidence

ORD record
ord-de594e43429f4eb49ac5316b68db3838
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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