Methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate → Methyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate

HRID 1435690Notes

Reaction equation

HRID 1435690 reaction equation
[NH2:1][C:2]1[S:3][C:4]([CH3:12])=[C:5]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[N:6]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22]([NH:1][C:2]1[S:3][C:4]([CH3:12])=[C:5]([CH2:7][C:8]([O:10][CH3:11])=[O:9])[N:6]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 2763571Methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetateHCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chloride

Product 1

HCID 86594955Methyl (2-{[(2,4-dichloro-6-methylphenyl)sulfonyl]amino}-5-methyl-1,3-thiazol-4-yl)acetate

Procedure

The title compound was prepared from methyl 2-(2-amino-5-methyl-1,3-thiazol-4-yl)acetate and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (27.2 mg) with purity >80%. MS (pos) m/z 409.0, 411.0.

Sources & evidence

ORD record
ord-9def2a3654674a32b3e6898457bfe6f7
Source dataset
uspto-grants-2009_11
Patent number
US07618961B2

Reaction notes

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