Hydrochloric Acid → 5-Amino-2-methylthio4-(3-methoxyphenyl)-quinazoline-6-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

Ethyl 5-amino-2-methylthio-4-(3-methoxyphenyl)-quinazoline-6-carboxylate (example 25d, 490 mg) was dissolved in 15 ml 1,4-dioxane and a 2 M aqueous KOH solution (3 ml) was added. The mixture was heated at reflux for 5 h and at 70° C. for 76 h. The mixture was cooled to room temperature and a 0.5 M HCl-solution in water was added. The mixture was extracted with CH2Cl2 (2×50 ml), the combined organic layers were dried (MgSO4) and concentrated under reduced pressure to yield the crude title compound.

Provenance & Evidence