反应详情

温度

70 °C

Ethyl 5-amino-2-methylthio-4-(3-methoxyphenyl)-quinazoline-6-carboxylate (example 25d, 490 mg) was dissolved in 15 ml 1,4-dioxane and a 2 M aqueous KOH solution (3 ml) was added. The mixture was heated at reflux for 5 h and at 70° C. for 76 h. The mixture was cooled to room temperature and a 0.5 M HCl-solution in water was added. The mixture was extracted with CH2Cl2 (2×50 ml), the combined organic layers were dried (MgSO4) and concentrated under reduced pressure to yield the crude title compound.

1. temperatureThe mixture was heated
2. temperatureThe mixture was cooled to room temperature
3. extractionThe mixture was extracted with CH2Cl2 (2×50 ml)
4. dry with materialthe combined organic layers were dried (MgSO4)
5. concentrationconcentrated under reduced pressure