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HRID1435771

反应详情

EQUATION

反应方程式

HRID 1435771 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：[Cl-].[NH4+]
HCID25517

未命名化合物

结构：C[O-].[Na+]
HCID10942334

Methanol, sodium salt

CH3NaO

结构：CCCC(=O)O[C@@H]1C[C@H](c2c[nH]c3ccccc23)c2ccccc21
HCID86618890

未命名化合物

PRODUCTS

生成物

1
结构：O[C@@H]1C[C@H](c2c[nH]c3ccccc23)c2ccccc21
HCID68910747

未命名化合物

收率 89.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

3 mL 30% NaOMe in methanol was added to 13.49 g butyric acid (1R,3S)-3-(1H-indol-3-yl)-indan-1-yl ester in 100 mL methanol. TLC showed full conversion after 1.5 hours. 1.5 g solid NH4Cl and 50 mL water were added. Methanol was removed in vacuo and after aqueous work up, (1R,3S)-3-(1H-indol-3-yl)-indan-1-ol (37.9 mmol ) was obtained.

WORKUP

后处理

  1. customafter 1.5 hours
  2. customMethanol was removed in vacuo