HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → cis-3-(1H-indol-3-yl)-indan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | butyric acid (1R,3S)-3-(1H-indol-3-yl)-indan-1-yl ester | HCID 86618890 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | cis-3-(1H-indol-3-yl)-indan-1-ol | HCID 68910747 | 89.7% |
Reaction Steps
3 mL 30% NaOMe in methanol was added to 13.49 g butyric acid (1R,3S)-3-(1H-indol-3-yl)-indan-1-yl ester in 100 mL methanol. TLC showed full conversion after 1.5 hours. 1.5 g solid NH4Cl and 50 mL water were added. Methanol was removed in vacuo and after aqueous work up, (1R,3S)-3-(1H-indol-3-yl)-indan-1-ol (37.9 mmol ) was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07618967B2 |
| Source dataset | uspto-grants-2009_11 |
| ORD ID | ord-43a20ef6ae0c4929a9655bac2755a109 |
| Source note | uspto-grants-2009_11 |