Hydrazine hydrate (1:1) → 5-Chloropyrazine-2-carbohydrazide

HRID 1435782Notes

Reaction equation

HRID 1435782 reaction equation
C[O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([Cl:11])=[CH:7][N:6]=1)=O.O.[NH2:13][NH2:14]>CO>[Cl:11][C:8]1[N:9]=[CH:10][C:5]([C:3]([NH:13][NH2:14])=[O:2])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 406081Methyl 5-chloropyrazine-2-carboxylate

Product 1

HCID 457897975-Chloropyrazine-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-chloro-pyrazine-2-carboxylic acid methyl ester (10.02 g, 58.25 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL) and the reaction mixture heated to reflux for 48 hours. The reaction mixture was then filtered and the precipitate collected dried in vacuo to yield the title compound, 5.01 g (50%).

Workup

  1. temperaturethe reaction mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationThe reaction mixture was then filtered
  4. customthe precipitate collected
  5. customdried in vacuo

Sources & evidence

ORD record
ord-90f36bffd1c045c7b8c2b08a54a649d1
Source dataset
uspto-grants-2009_11
Patent number
US07618972B2

Reaction notes

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